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Neuromuscular blockade and reversal

The Primary () and Final () FRCA examinations require an extensive knowledge of neuromuscular transmission blocking agents. We have therefore written a new pharmacology resource section.

The tutorials have been tailored to the FRCA syllabus and we have also added some past questions relevant to these topics.

 Primary FRCA Syllabus



 Muscle relaxants.  Classification. Sites of action. Properties of an ideal muscle relaxant. Dantrolene and management of MH….Depolarizing muscle relaxants: Structure, mechanism of action. Organophosphate poisoning. Adverse effects and contraindications....Non-depolarizing muscle relaxants: Structural classification; sub-classification according to onset-time and duration of action. General comparison of aminosteroids and bisbenzyisoquinoliniums. Comparison of individual agents; metabolism and active metabolites. Unwanted effects.....Reversal of neuromuscular blockade: Indications for use; mechanisms of action; clinically unwanted effects of reversal of neuromuscular blockade 




 Final FRCA Syllabus

Applied Clinical Pharmacology

Management of neuromuscular blockade… techniques for the use and reversal of muscle relaxants ….

Pages in this section

The neuromuscular junction
Mechanism of action of neuromuscular blocking drugs
Pharmacology of the non-depolarising muscle relaxants
Assessing neuromuscular block
Peripheral nerve stimulators
Stimulation patterns and their use
Objective monitoring
Priming principle
NMBs in patients with neuromuscular disorders


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