The management of anaphylaxis due to latex is the same as for all other causes of anaphylaxis. See below for an illustration of the immunological mechanisms of anaphylaxis.
1] Antigen is internalised by the antigen-presenting cell (APC).2] The internalised antigen is processed within the APC.3] The APC presents the processed peptide to CD4+ T lymphocytes via the major histocompatibility complex II.4] After the peptide is presented, the T cell differentiates into TH2 T lymphocytes and produces cytokines. These then cause B cell immunoglobulin isotypes to switch to IgE.6] Circulating IgE binds to IgE receptors on mast cells.7] Antigen similar to the original antigen cross-links the mast cell with surface-bound IgE and results in cellular degranulation. Click here to view the guidelines produced by The Association of Anaesthetists. NB. Mini-jets of resuscitation drugs are latex-free.The patient must be closely monitored on the intensive care unit/high-dependency unit for at least 24 hours as further symptoms may occur.
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